Changes in serum lipid profile of albino rats fed on canola oil supplemented with atherogenic elements: 18 weeks study

Amongst lipid lowering factors, the dietary intervention for treating hyperlipidaemia and atherosclerosis associated ailments is physiological and gratifying. Canola is rich in monounsaturated fatty acids and is locally cultivated and cost effective. The criterion of the study was to determine the status of serum lipid profile in albino rats fed on canola oil diets for prolonged period of 24-weeks and to compare the same with those fed on canola oil supplemented with atherogenic elements. Results demonstrate that moderate amounts of canola oil [2.9% in diet] has triglyceride and cholesterol lowering effects. Both moderate and high amounts of canola oil [20%] decrease serum LDL-c profiles and resist lowering of HDL-c levels in rats fed with canola oil alongwith atherogenic elements. Conclusions: These findings reveal canola oil amongst the important supplement of monounsaturated fatty acids in animals and these findings may be generalized for humans

Serum lipid profile in patients of acute and transient psychotic disorders

Forty subjects, aged 15-45 years were randomly selected. Subjects were separated age wise into 1st group [15-30 years] and 2nd group [31-45 years]. They were divided into groups A and C. Group A included twenty patients of acute and transient psychiatric disorder while group C includes 20 age and sex matched normal controls. Serum total cholesterol [TC], Serum triglyceride [TG], Serum HDL-c and Serum phospholipid were done by using colorimetric methods. Serum LDL-c was calculated by Friedwald equation. Results obtained were analyzed by using students 't' test and level of significance was done. Altered lipid metabolism was found in patients of acute and transient psychotic disorders with decreased Serum TC, LDL-c and phospholipids

Significance of thyrotrophin and thyroxine estimations in type 1 diabetes

OBJECTIVE: To investigate whether estimation of thyrotrophin [TSH] and thyroxine [T4] is significant to assess the thyroid status of diabetic patients. MATERIALS AND METHODS: Fifty patients with type 1 diabetes [25 male and 25 female] aged 9-50 years were included. The mean duration of diabetes was 6.7 +/- 4.3 years. Clinically they were not suffering from any systemic disease or endocrine ailment. Twenty-six, age and sex matched, normal controls were also included. The TSH and and T4 were estimated in the sera of all the subjects using the commercially available ELISA kits. The mean +/- SD concentration of TSH was raised significantly [p < 0.001] in the patients as compared to the controls, whereas the T4 concentration was comparable. Furthermore, 30% diabetics showed significantly elevated TSH concentration than the controls. It is proposed that the estimation of TSH in the patients with type 1 diabetes may be useful in the early identification of thyroid dysfunction